One of the most elegant batsmen of his era, Martin Crowe now has the toughest battle on his hands after the former New Zealand captain was diagnosed with lymphoma, an invasive cancer of the immune system.The 50-year-old Kiwi received the news only recently, his manager Louise Henderson said, adding Crowe and his family had requested privacy in dealing with the news.”The family has a number of issues to confront over the next couple of weeks. The diagnosis is very new, the family is still in shock and obviously dealing with the understanding that life as they know it for the unforeseeable future is different.”Crowe, famous for his cover-drive and flicks off his pads, gave immense joy to cricket lovers in 77 Tests and 143 One-Day Internationals between 1982 and 1995.He, along with legendary all-rounder Richard Hadlee, presided over a successful period for New Zealand cricket in the 1980s. As captain, his great achievement guided his team to the semi-finals of the 1992 World Cup, which New Zealand co-hosted with Australia. The Kiwis won seven of their eight roundrobin matches, before bowing to eventual champions Pakistan in the last four.During his pomp, Crowe had been admired for having a great deal of time to play the fastest bowlers in the world. Former Pakistan speedster Wasim Akram was candid enough to admit that Crowe was the best in handling the reverse swing unleashed by him and Waqar Younis.Crowe was named as one of Wisden’s Cricketers of the Year in 1985, and his 299 against Sri Lanka in 1991 still remains the highest Test score by a New Zealand player. He also had a stint with English county Somerset between 1984 and 1988.He could have played much more at the highest level, but his body did not always cooperate. His broken shin, back trouble, torn hamstrings and serious knee injuries did not allow him to get on the park as much as he would have liked.Crowe, whose brother Jeff also played Test cricket for New Zealand, did not have an auspicious start to his Test career. He even wondered whether he had what it took to succeed at the highest level. It only shows his mental strength that he went on to achieve what he did. After retirement, he has been an outspoken voice in the media, and was even involved with Indian Premier League side Royal Challengers Bangalore for a while.advertisement
Australia has taken out all three divisions, and all nine games at the 2017 Trans Tasman Test Series.This is the second-time Australia has completed a clean sweep of the whole series in Trans Tasman history.Stay tuned to the website and our social media channels for highlights from the 2017 Trans Tasman series.Congratulations to team Australia on the clean sweep.Mixed OpenGame One: Australia (9) defeated New Zealand (6)Australia 9 (Opie-Lukins 2, Benbow 2, Blackwood, Costello, Nicholas, Mortimer, Pryde touchdowns) defeated New Zealand 6 (Morgan-Puterangi 2, Rauwhero, Ashworth, Drummond, Haugh touchdowns)Game Two: Australia (14) defeated New Zealand (7)Australia 14 (Mortimer 2, Pryde 2, Nicholas 2, Lang 2, Blackwood, Costello, Townson, Benbow, Parker, Singh touchdowns) defeated New Zealand 7 (Hodson 2, Takerei 2, Drummond, Rauwhero, Morgan-Puterangi touchdowns)Game Three: Australia (11) defeated New Zealand (10)Australia 11 (Glazebrook 2, Singh 2, Nicholas, Mortimer, Costello, Opie-Lukins, Pryde, Lang, Percy touchdowns) defeated New Zealand 10 (Parsons 3, Gardiner, Stephens, Rollinson, Waudby, Morgan-Puterangi, Jones, Takerei touchdowns)Womenâ€™s OpenGame One: Australia (10) defeated New Zealand (3)Australia 10 (Upton 3, D. Davis 2, Peattie 2, R. Davis, Kearney, Rodgers touchdowns) defeated New Zealand 3 (Engler, Day, Paul touchdowns)Game Two: Australia (9) defeated New Zealand (6)Australia 9 (Watego 2, Peattie 2, Rodgers 2, Kearney, Upton, Dyball touchdowns) defeated New Zealand 6 (Tainui-McIntyre 2, Hopcroft, Mohi, Mahar, Engler touchdowns)Game Three: Australia (14) defeated New Zealand (3)Australia 14 (Watego 2, Peattie 2, Rodgers 2, Michaelopolous 2, McCall, Sargent, Maddick, R. Davis, Upton, Crowe touchdowns) defeated New Zealand 3 (Hotham, Mahar, Evison touchdowns) Menâ€™s OpenGame One: Australia (9) defeated New Zealand (4)Australia 9 (Marshall King 2, Prowse 2, Buckley 2, Norman, Brisby, Springfield touchdowns) defeated New Zealand 4 (Loloselo, Soutar-Finch, Law, Pamatatau touchdowns)Game Two: Australia (7) defeated New Zealand (6)Australia 7 (Prowse, Norman, Good, Brierty, Toner, Francis, Green touchdowns) defeated New Zealand 6 (Cavanagh, Soutar-Finch, Stone, Robinson, Rhind-Rogers, Kake touchdowns)Game Three: Australia (7) defeated New Zealand (3)Australia 7 (Green 2, Hoch, Prowse, Good, Norman, Francis touchdowns) defeated New Zealand 3 (Soutar-Finch 2, Quinn 2, Robinson, Graham touchdowns)Related LinksTT Results
AUSTIN, TX – SEPTEMBER 5: Fans cheer on the Texas Longhorns against the Louisiana Monroe Warhawks on September 5, 2009 at Darrell K Royal-Texas Memorial Stadium in Austin, Texas. (Photo by Brian Bahr/Getty Images)Texas Longhorns fans who made the trek up to Notre Dame, Indiana, weren’t thrilled with the result from the game this past Saturday. But at least one UT supporter still had great things to say about the Fighting Irish and their fan base. A Texas fan named Terry Bader penned a cool ‘thank you’ letter to Notre Dame and its fans for their “remarkable hospitality” this past weekend. It was published by The Observer Thursday morning. The school tweeted out a photo of the letter – check it out:A Texas Longhorn fan wrote a thank you letter to The Observer. Well done, Irish fans READ: http://t.co/ppS4VslodZ pic.twitter.com/OxKfDSphqQ— The Fighting Irish (@FightingIrish) September 10, 2015It’s a refreshing story – especially considering we typically only hear tales on the other end of the spectrum. Well-done to all involved here.
cordavien suggs top 10Three-star offensive tackle Cordavien Suggs, a 6-foot-6, 260-product of Neptune Beach, Florida, has announced his top 10 schools. Suggs, who is a class of 2017 player, has four SEC programs on his list – along with three ACC schools. He has an interesting mix of programs – from Florida to FAU.Suggs’ list is not in order – and he joked after that he should have presented it in alphabetical order. Check it out:My current Top 10 #Hailstate #Swamp17 #VolNation #Gamecocks #TarHeels #OwlsUp #Wazzu #StripeEmUp #GoCardinals #GT pic.twitter.com/1JpkakxukP— Cordavien Suggs (@_73era) May 18, 2016I really should’ve did that list in alphabetical order— Cordavien Suggs (@_73era) May 18, 2016Suggs is crystal-balled to Mississippi State, according to 247 Sports.
zoomImage Courtesy: Offshore and Home Trade Seamen’s Welfare Trust Undisclosed shipping lines have attempted to conduct self-handling in a number of Italian ports, according to the European Transport Workers’ Federation (ETF).Self-handling, which represents the use of seafaring onboard staff to load or lash cargo, rather than local dockers, was reported at the Italian ports of Palermo, Termini Imerese, Trapani and Porto Empedocle.The ETF has addressed a letter to the Port Authority for the Western Sicilian Sea urging that the law is properly enforced.“Italian law is very clear on the circumstances where shipowners can be allowed to ask their crew to perform cargo-handling tasks such as lashing and unlashing,” Terje Samuelsen, ETF Dockers’ Chair, said.“In the case of the Sicilian ports, the required conditions, such as the non-availability of dockers, are not met. These are not isolated attempts, as we have been informed by our members, and we are taking them very seriously,” Samuelsen added.Reclaiming lashing is one of the priority fights for ETF and ITF Dockers’ unions, also in the framework of the Fair Transport Europe Campaign 2.0.In a context of growing automation and decreasing cargo volumes, lashing by dockers is an important way to retain port jobs. Moreover, lashing operations are very dangerous and should only be performed by qualified dockers, ETF informed.Seafarers should not do lashing, because they are not properly trained for such operations and because they are often required to do lashing during their rest time.In the framework of the International Bargaining Forum (IBF) negotiations, the ITF and the JNG have agreed on a new text of the so-called dockers’ clause which is expected to deter self-handling on board Flag of Convenience (FOC) vessels. However, ETF reported that self-handling attempts were reported not only on FOC vessels, but also on those flying national flags.“Our Italian members estimate that in the case of the Sicilian ports, allowing an exemption to the law would cost up to 500 dockers’ jobs,” declared ETF Dockers’ Vice-Chair Torben Seebold.
Romanian DTH operator Focus Sat has added three HD channels and a new movie package to its line-up.The UPC-owned company is launching an HD service consisting initially of Discovery HD, ESPN HD and Sundance HD America. It is available at no extra cost to Familia package subscribers until the end of the year. The operator said it would add four new channels in January. Focus Sat is also adding GSP TV, Fishing and Hunting, SkyNews and Bloomberg to the Familia package.In addition, the operator has added the FilmBox package of channels, which includes the FilmBox Family and FilmBox Extra 1 channels to its line-up and is available at no additional cost to all Focus Sat subscriber until 31 December. From next year it will cost RON11 (€2.50) per month.
German broadcaster ProSiebenSat.1’s sports business unit, 7Sports, is to deepen its involvement in the fast-growing world of eSports for the first time after striking a deal with Modern Times Group (MTG)-owned eSports giant ESL.From August 30, the ProSieben Maxx channel will run a new magazine show, Ran eSports. The content will also be available on the ran.de and ProSiebenMAXX.de websites. ProSiebenSat.1 claims that the show, which will air every Wednesday at 00:15, will be the first on a German free-to-air channel dedicated to eSports.The show will focus on Counter Strike: Global Offensive, but will also feature content around the League of Legends game as well as Dota 2, FIFA, Madden NFL and Rocket League.Before the launch of the magazine show, ProSieben Maxx will also air the final of the FIFA Interactive World Cup on August 23.The broadcaster has also renewed an existing agreement with eLeague. ProSieben Maxx started broadcasting content from the Turner-backed sSports league last year.7Sports CEO Zeljko Karajica said that eSports was “one of the major growth areas in sport” and that taking the content to free TV would open it up to a new audience. He said the partnership with ESL, together with the group’s existing eLeague, meant that ProSiebenSat.1 now had one of the largest line-ups of eSports on offer.
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Treatment strategiesIt is difficult to treat this cancer because of its location. One technique is called transurethral resection. A cutting instrument is passed through the urethra, the tube that takes urine out of the body, to remove all the visible part of the cancer. However, this has been associated with recurrence in 50% to 70% of patients. Moreover, 10% to 20% of patients develop progressive cancer over the next 2-5 years.A second treatment strategy is to stimulate the immune response to the tumor using a live bacterium called Bacille Calmette-Guerin, or BCG, which has already been widely used to confer childhood immunity to tuberculosis. However, it is ineffective in one out of three bladder cancers, while another third of patients experience severe adverse effects following its use.How CVA21 acts on bladder cancersRelated StoriesHow cell-free DNA can be targeted to prevent spread of tumorsBacteria in the birth canal linked to lower risk of ovarian cancerSugary drinks linked to cancer finds studyTypical bladder cancers lack immune cells, and are ‘cold’ with respect to the immune system. CVA21 acts by infecting cancer cells and then undergoing replication. It then bursts open the cell so that the new virus particles can escape.During this process, the coxsackie virus also activates various genes concerned with inflammation and immunity, making the tumor immunologically ‘hot’. Such tumors are less likely to grow significantly before they are eliminated by the immune system.In treated patients, the shed virus was detected in urine tested on alternate days. This proves that the virus continues to infect new cancer cells within the bladder once it has killed the cells first infected.In the current study, CVA21 was run into the bladder of 15 patients, one week before they were to have their tumors removed surgically. Of the 15, six received only the virus, while the next nine patients also got a dose of mitomycin C. This is a known chemotherapy drug, but its dosage was reduced to subtherapeutic levels. Its administration was intended to increase the expression of the molecule ICAM-1 on the surface of the cancer cells. This molecule attracts and binds the CVA21 virus and thus enhances its oncolytic activity.After the surgery, tissue biopsy samples showed that the CVA21 virus selectively attacked only the cancer cells in the bladder, while sparing all normal cells. In all cases the tumor showed bleeding and inflammation, indicating that it was being attacked by the virus.In one of the 15 patients, the tumor disappeared completely and was not found during surgery. There were no significant adverse effects or toxicities reported in any patient.The benefits of CVA21 for NIMBC immunotherapy thus include a good safety profile, selective targeting of bladder cancer cells by the virus, viral replication within the tumor cells with resulting tumor cell death, and virally-mediated tumor inflammation to induce immune attack of the tumor, all leading to its destruction.Researcher Hardev Pandha explains the motivation for the current work: “Non-muscle invasive bladder cancer requires an intrusive and often lengthy treatment plan. Current treatment is ineffective and toxic in a proportion of patients and there is an urgent need for new therapies. [With coxsackievirus] reduction of tumor burden and increased cancer cell death was observed in all patients, showing its potential effectiveness.” Journal reference:Viral targeting of non-muscle invasive bladder cancer and priming of anti-tumour immunity following intravesical Coxsackievirus A21, Nicola E Annels, David Mansfield, Mehreen Arif, Carmen Ballesteros-Merino, Guy R Simpson, Mick Denyer, Sarbjinder S Sandhu, Alan Melcher, Kevin J Harrington, BronwYn Davies, Gough Au, Mark Grose, Izhar N Bagwan, Bernard A. Fox, Richard G Vile, Hugh Mostafid, Darren Shafren and Hardev Pandha, Clin Cancer Res July 4 2019 DOI: 10.1158/1078-0432.CCR-18-4022, http://clincancerres.aacrjournals.org/content/early/2019/06/29/1078-0432.CCR-18-4022 By Dr. Liji Thomas, MDJul 8 2019Scientists in the UK have found a new way to treat bladder cancer, using a strain of one of the viruses that cause the common cold. The virus is called Coxsackie virus CVA21, and it was found to be oncolytic, or tumor-destroying. This new research demonstrated virus-mediated destruction of the tumor in all treated patients, and in one of them, the tumor disappeared completely. Bladder cancer, CT – Illustration Credit: Semnic / Shutterstock Investigator Nicola Annels of the University of Surrey points out that while viruses are typically thought of in a negative sense, they can be used to enhance health and bring healing in the case of cancer cells. She says: “Oncolytic viruses such as the coxsackievirus could transform the way we treat cancer and could signal a move away from more established treatments such as chemotherapy.”In this study titled, “Viral targeting of non-muscle invasive bladder cancer and priming of anti-tumour immunity following intravesical Coxsackievirus A21”, CVA21 was used to treat 15 patients who had bladder cancer that had not yet spread into the muscular wall of the bladder. This is called non-muscle invasive bladder cancer (NMIBC) and is found in one out of every 10 cancer patients in the UK. About 10,000 people are found to have the disease each year.