View post tag: presence View post tag: Royal View post tag: Australian Royal Australian Navy to Re-establish Naval Presence on Thursday Island THE Royal Australian Navy should urgently re-establish a naval presence on Thursday Island off Cape York or risk a major border security bre…By Mark Dodd (theaustralian)[mappress]Source: theaustralian, June 27, 2011; Back to overview,Home naval-today Royal Australian Navy to Re-establish Naval Presence on Thursday Island View post tag: Re-establish June 27, 2011 View post tag: Thursday View post tag: News by topic Authorities View post tag: Navy View post tag: Naval View post tag: Island Share this article
What does it mean to really do this?by: Paul Seibert, CMCLiving. Your. Brand. These three words are easy to say and even sound like something good to do. But how many of us are truly doing it? And what does living your brand actually look like anyway?The importance of living your brand has significantly increased over the past few years in light of increased competition, rising market expectations, and the need to create a unique, engaging, and motivating experience for members and staff. Because of this, I interviewed Karen McGaughey, VP/client services at Weber Marketing Group, Seattle, to get a better handle on the idea.Q&A With Karen McGaugheyPaul: What does living the brand mean?Karen: Brands are built through experiences and interactions. Living the brand requires an organization to be brand-focused in all its delivery channels. This includes how the brand is conveyed externally to target audiences, in the online user experience, and through the service delivered inside a branch. Two of the most overlooked components of living the brand is what it means to employees as well as what the expectations are of direct member-interfacing staff compared to those who function in a back-office role. Should the expectations be different? My answer is no. To build a brand culture and deliver rich member experiences, all staff needs to be operating from a consistent set of actions and behaviors that reflect a distinctive brand. continue reading » 4SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
An undisclosed European pension fund has tendered a $300m (€280m) global emerging market bond mandate using IPE Quest.The client is open to splitting the mandate in two, for $150m each.According to search QN-2144, the tender calls for an active investment process.Performance should be measured against a benchmark composed of JP Morgan’s diversified global emerging market sovereign index (60%) and its corporate bond index (40%). The client expects a maximum tracking error of 5%.Applicants should have a track record of at least five years and at least $5bn in assets under management, $2bn of which should be in bonds.Experience with managed or segregated accounts is essential, according to the mandate.The client is only seeking investments in “hard currency”, adding that no local currency exposure is “desired at this point in time”.Interested parties should state performance, gross of fees, to 31 December. Applications should distinguish between the asset management company’s process for emerging market government bonds and emerging market corporate bonds.Eight to 12 portfolio managers are likely to be long-listed. Conference calls with these candidates will probably take place the week of 29 February, with on-site due diligence provisionally targeted for the week of 25 April.The deadline for applications is 18 January. The IPE news team is unable to answer any further questions about IPE Quest tender notices to protect the interests of clients conducting the search. To obtain information directly from IPE Quest, please contact Jayna Vishram on +44 (0) 20 3465 9330 or email [email protected]
Switzerland’s pension fund association has called on stakeholders to be ready to compromise to ensure the passage of a pension reform package, issuing its appeal ahead of a parliamentary committee hearing on the measures.The association, ASIP, issued its appeal earlier this week to coincide with the second reading of the Swiss government’s reform package, Altersvorsorge 2020 (AV2020), by the social security and health committee (SGK-N) of the lower house of parliament, or Nationalrat.Hans-Peter Konrad, ASIP’s director, said the association hoped for a successful resolution.“We want AV2020 to succeed,” he told IPE. “To do so we need a proposal that fairly distributes the burden across citizens, beneficiaries, and employers.” “Reform is needed of the first and second pillar, and we support the comprehensive reach of the reform,” he added.ASIP believes that the upper house of parliament, the Ständerat, which has already debated the AV2020 reform package, has come up with a proposal that is “more or less acceptable”, according to Konrad, and hopes for a similar outcome from the SGK-N.Key reform areasASIP highlights three areas of reform, including the harmonisation of retirement ages for both men and women to 65. It also says pension funds should retain the ability to offer benefits from age 60, and backs lowering the so-called conversion rate with certain measures in place to offer compensation.ASIP said that it supports the proposal from the Ständerat to lower the conversion rate, which is used to calculate the pension benefits from accrued assets, from 6.8% to 6%, even though it thinks that from a technical perspective it should be even lower, namely 5.5%.“But we know that politically this is not feasible,” Konrad told IPE.The association believes that the 6% proposal “goes in the right direction” and can be accepted as the basis for the calculation of accompanying measures to mitigate the impact of the lower conversion rate.Crucial for ASIP is that these compensating measures are taken within the second pillar, and not within the state system.The measures to maintain the pensions level should be limited to a 10-year period and should be “decentralised”, in other words be left up to each individual pension provider to come up with a solution.The Ständerat’s reform proposal involves a centralised model, under which a protection fund would be responsible for financing the compensation for the lower conversion rate.ASIP is against this centralised approach, in part because it considers it too complicated.The Nationalrat committee proposed modifications to the AV2020 reform proposal this afternoon (19 August), saying that it needs to be further developed during parliamentary debates.One of its main decisions, it said, was to reject as “counterproductive” measures proposed by the Ständerat to compensate for the targeted lower conversion rate and higher retirement age for women.The Ständerat’s proposal included first pillar supplements, which the Nationalrat committee today said would burden future generations without representing a structural solution to the problem of financing the state pension. It has come up with alternative measures to compensate for the lower conversion rate, which it has also backed being set at 6%.
Sven AaserTelenor Group has announced its intention to divest all its shares in Russian operator VimpelCom, where the company has an economic stake of 33%. Telenor Group will now fully focus on creating value in core operations.Telenor said that VimpelCom has gradually contributed less to the value of the group, and the value of Telenor’s core operations have increased rapidly. Today, the market value of the VimpelCom Ltd. shares represents approximately 8% of Telenor’s market capitalization.Telenor Group has invested NOK 15 billion (€1.6 billion) in VimpelCom. The company has received NOK 20 billion in dividends and the current market value of the ownership stake is approximately NOK 20 billion.Telenor said it will explore all options to divest its shares in VimpelCom and will seek to find the best solution for Telenor and its shareholders. A timeframe for the divestment has not been set, but is expected to take some time.The Vimpelcom stock declined in the third quarter and ended at US$4.11 per share versus a book value of US$5.64 per share, leading to Telenor making a non-cash impairment of approximately NOK7.5 billion in the third quarter.“The VimpelCom asset, where Telenor holds a minority position without the possibility to fully control the company, has been challenging. Based on a strategic review by the Board and the CEO, and after due considerations, Telenor Group has decided to divest its shares in VimpelCom Ltd. The disposal of our shares is in the best interest of our shareholders, and in accordance with Telenor Group’s long-term strategic focus,” said Svein Aaser, Chairman of the Board of Directors of Telenor Group.
The discovery of TOX as the key regulator of exhausted T cells now allows us to envision immunotherapies that target, or engineer, TOX to reverse or prevent exhaustion and improve immunity to infections or cancer.”Senior author E. John Wherry, PhD, chair of the department of Pharmacology and director of the Penn Institute of Immunology Reviewed by James Ives, M.Psych. (Editor)Jun 18 2019The human immune system relies on a delicate balance of finely tuned cell types that keep germs and cancerous cells in check. In cancer and chronic infections this balance can be disrupted, resulting in immune system dysfunction or “exhaustion.”An important protein called TOX, which varies in amount in different immune cell types, controls the identity of the cells that become exhausted, according to researchers in the Perelman School of Medicine at the University of Pennsylvania. With this knowledge, investigators now have a way to accurately identify immune cells that are exhausted in a tumor or site of an infection, which could allow clinicians to improve the effectiveness of patients’ immune response to cancer treatments by reinvigorating exhausted T cells. This work is published this week in Nature. The T cells the team studied come in three varieties and rely on efficient and coordinated transitions between different identities. Following initial activation by specific proteins, immature T cells replicate and undergo an orchestrated program of molecular rewiring to become effector T cells (TEFF), which produce inflammatory cytokines that kill offending cancer and germ cells.If an infection or tumor is cleared, most of the TEFF pool dies, but a subset persists. This set undergoes more rewiring and forms long-lived, self-renewing memory T cells (TMEM) capable of mounting a rapid recall response should an invader be detected a second time. However, during chronic infections or with cancer, when T cell stimulation is drawn out, this program of T cell differentiation is diverted and the cells becoming ineffective against the tumor or infection-;instead, they become exhausted. But, these exhausted T cells (TEX) are not totally useless. In fact, they may keep low-level germ or tumor presence in the body in check.Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsNew protein target for deadly ovarian cancerStudy reveals link between inflammatory diet and colorectal cancer riskIn this battle, Wherry likens TEX to an infantry that performs the day in and day out work of containing minor assaults, such as long-term infection by the herpes virus. On the other end of the spectrum, TEFFs are like calling in the Navy SEALs.”They get the job of containment done, and quickly, by whipping up a cytokine storm, but there is the collateral damage of an overactive inflammatory response,” Wherry said. TEX are not strong enough to cause an increased inflammatory response, and in some cases, may strike a necessary balance between partially containing an infection or tumor without causing excessive damage to the host.The longer TOX is expressed in a T cell the more permanent the TEX identity becomes. The level of TOX in a T cell dictates how an infection or tumor is contained by controlling the number of TEFF versus TEX cells. High and sustained induction of TOX results in the permanent existence of TEX, but the consequences of a restrained ability to fight invaders can be the persistence or progression of disease.The team also showed that TOX shapes cell identity by making the spools on which genes are wound in the nucleus more or less available to be translated into proteins. This ability of TOX to shape the structure of a cell’s genome via its epigenome also provides insight into why changing TEX into TEFF has been difficult with other therapies. Epigenetic changes help “lock” cells into their permanent identity, but these new findings may allow researchers to change that for future immunotherapies. Source:Penn Medicine